Synthèse en série hétérocyclique

Abstract

In this manuscript we are interested in the development of multi-component reactions by studying the catalytic power of new catalysts on some of them: the Hantzsch reaction and synthesis of tetrahydrobenzo [b ] pyrans. In the first part we studied the effect of three catalysts, which are bismuth triflate, 2,6-diaminopyridine and piperazine on the Hantzsch reaction to access to the polyhydroquinolein derivatives with good yields. In the second part our research helped to develop a new path to the tetrahydro[b]benzopyrans, another class of heterocycles with very interesting biological and medicinal properties, using a Lewis acid as catalyst which is phenylboronic acid which has the advantage of being non-toxic, low-cost and easily work-up. The obtained yields are good to excellent.