الخلاصة:
This investigation is interested to study the mo dulator effect of Linaria tingitana in rats
treated by the valproic acid (VPA). The in vitro studies (DPPH ◦, FRAP, β-carotene, Chelation, NO ◦) showed that Linaria tingitana is endowed with an antioxidant property. The antiinflammatory studies (albumin denaturation, HRBC, NO scavenger, oedema and peritonitis led
by the carrageenan, the rise of MPO and the infiltration of the PN) confirmed that Linaria
tingitana has a beneficial effect in this sense. The in vivo studies made to rats handled by the
VPA revealed that the n-BuOH extract acts by a multitude of mechanisms: conservation of the
hepatic function, the modulation of the steatoses, the neutralization of the oxidative stress and
the reduction of the inflammation hepatocyte elucidated by the decrease of the activity MPO.
Antirrhides molecules isolated of this plant were ineffective at the level of the cell line HepG2
treated with the VPA. The mitochondrial dysfunction led by the VPA is expressed by the decrease of the RCR accompanied by a decrease of the activity of the complex I. The n-BuOH
extract as well as the isolated molecules managed to reduce the mitochondrial H2O2 and to modulate the antioxidant mitochondrial and lysosomal systems. The conservation of the integrity
lysosomal membrane was more pronounced by the n-BuOH extract compared to the vitamin
E. The various modulator ways of L. tingitana delayed the appearance of the complications
linked to the mitochondrial dysfunction, lysosomal, such necrosis. Probably this is due to the
diversified wealth of this plant in term of polyphenols and irridoids revealed by phytochemical
screening and the analysis of the LC-MS and in the synergetic effect of the molecules that it
contains
