Recherche et détermination structurale de métabolites secondaires de Matricaria Chamomilla (Asteraceae)

Abstract

The main purpose in this work was, the isolation and the structural détermination of the secondary metabolites of the flavonoids type from the nbutanol phase of the aerial parts of Matricaria chamomilla species belonging to the Asteraceae family. Our choice for this species is justified by the fact that several species of the geans Matricaria are used in folk medicine for their anti-inflammatory, antibacterial, anti-ulcerative , antipyretic ,antispasmodic activities, for treatment of gastrointestinal disorders and against uterine shrinkages… This study relates to the phytochemical investigation of the n-butanol phase of the aqueous-alcoholic extracts of the leaves and the flowers of Matricaria chamomilla. This contribution led to the isolation of seven products in the pure state, from which, we have established the structure of to products. - Luteolin-7-O-β-glucoside. - 5, 6, 7,3’,4’-pentahydroxyflavone-4’-O-β-D-glucoside. The isolation and structure determenation of isolated coumpounds were based on the different spectroscopic technics such as ultraviolet, 1H NMR, 13C NMR, 2D NMR experiments (COSY, HSQC, HMBC) and mass spectrometry. It is important to note, that 5, 6, 7, 3’,4’-pentahydroxyflavone-4’-O-β-Dglucoside is new and then ,was not described elsewhere.