Synthèse de nouveaux 1,2,3-triazoles adamantylés et de chalcones dérivés du diméthyle-3,5-adamantane.

Abstract

The work described in this thesis is part of a program to develop new heterocyclic molecules with therapeutic potential, including adamantane, triazoles, chalcones and pyrazolines. Several types of reactions are involved, in particular one of the variant of the click chemistry that is the copper-catalyzed (I) 1,3-dipole cycloaddition [3 + 2] of Huisgen where our choice is carried after several tests on copper acetate Cu(OAc)2, H2O as a catalyst. The thesis is divided into 2 chapters. The first is a bibliographic overview on the chemistry ""click"" and the importance of 1,2,3-triazoles in medecine and biotechnology, before the description of our work concerning the synthesis of 4-substituted 1,2,3-triazoles 1- (4- adamantylbenzyl),. In the second chapter, we presented some examples on the biological importance of chalcones, the methods of their synthesis as well as their reactivity then the work done for the elaboration of a series of new compounds. One party will then do the reactivity study plan with respect to 1,4-addition; which gave with the hydrazine some new derivatives with pyrazoline cycle. The adamantane nucleus making a branch common to all the products of our synthesis, we devoted to it a bibliographic preview before the first chapter. The structural characterization was carried out using one-dimensional and twodimensional NMR( COSY, HSQC, HMBC ), mass spectrometry and XRD. Returns are generally satisfactory. Given the nature of the synthesized molecules, their originality, they will be the subject of various biological tests.