Débenzylation, détritylation des indoles et nouvelle méthode de synthèse de (Rs) N-Tert-Butanesulfinylimine.

Abstract

This manuscript describes the reductive removal of trityl and benzyl groups from N-protected indoles, using indium, magnesium, zinc and aluminum processes and new method for synthesis an N-tert-Butanesulfinylimines. In the main part: Chapters 1 and 2 we have reported the development of two efficient processes one for transforming a wide variety of indoles into the corresponding derivatives indoles in high yield, using a simple and soft protocol, and other to protect indoles which is our starting materials. Chapter 3 shows the deprotection of the trityl (triphenylmethyl) and benzyl groups, from tritylated and benzylated indoles using indium, magnesium, zinc and aluminum powder to give the corresponding free indoles. In the second main part: we have described anew method for the synthesis ofN-tertButanesulfinylimines with a moderate yield.