المستودع الرقمي في جامعة الإخوة منتوري قسنطينة 1

Nouvelles voies de Synthèse des 1,4-dihydropyranopyrazoles, tétrahydrobenzo[b]pyranes et β-acétamidoacétones.

عرض سجل المادة البسيط

dc.contributor.author Ziadi Chibane, Adil
dc.contributor.author Dedache, Abdelmadjid
dc.date.accessioned 2022-05-25T08:23:50Z
dc.date.available 2022-05-25T08:23:50Z
dc.date.issued 2018-09-23
dc.identifier.uri http://depot.umc.edu.dz/handle/123456789/8151
dc.description.abstract The work undertaken through this thesis is part of the development of new procedures for the synthesis of molecules of biological interest, through multi-component reactions. The results obtained are presented in three main chapters: -In the first chapter we studied the catalytic effect of aluminum acetylacetonate on a fourcomponent reaction to access to 1,4-dihydropyrano [2,3-c] pyrazoles derivatives and wen proposed the optimal conditions for obtaining them with good yields. -The second chapter was devoted to the catalytic power of the same catalyst on the threecomponent synthesis of tetrahydrobenzo [b] pyrans, which have also been obtained, in general, with good yields. -As for the third chapter, it was devoted to the development of a new pathway to β- acetamidoketones, another class of molecules with interesting biological and medicinal properties, using phenylboronic acid, a Lewis acid catalyst, which has the advantage of being nontoxic, inexpensive and environmentally friendly. The yields obtained are good to excellent. In addition, the inhibitory activities of acetylcholinesterase and butyrylcholinesterase of certain molecules have been examined and proved to be of interest. All the synthesized products were identified by the usual spectrometric analyzes (IR, 1H NMR and 13C NMR).
dc.language.iso fr
dc.publisher Université Frères Mentouri - Constantine 1
dc.subject dihydropyrano [2,3- c]pyrazoles
dc.subject tétrahydrobenzo[b]pyranes
dc.subject β-acétamidocétones
dc.subject réactions multicomposants
dc.subject acide phénylboronique
dc.subject acide de Lewis
dc.subject acétylacétonate d’aluminium
dc.subject anti acétylcholinestérase
dc.subject anti butyrylcholinestérase
dc.subject β-acetamido ketones
dc.subject multicomponent reactions
dc.subject phenylboronic acid
dc.subject Lewis acid
dc.subject aluminum acetylacetonate
dc.subject anti acetylcholinesterase
dc.subject anti-butyrylcholinesterase
dc.subject 4 ,1ديهيدروبيرانو[-3،2ج] بيرازول
dc.subject ثيثراهيدروبانزو[ب]بيران
dc.subject بيثأسيثأميدو سيثون
dc.subject تفاعلات متعددة المركبات
dc.subject حمض فينيل بورونيك
dc.subject حمض لويس
dc.subject أسيتسيل أسيثوناث الألمنيوم
dc.subject ضد الأسيتيل كولين استيراز والبيتيغيل كولين استيراز
dc.title Nouvelles voies de Synthèse des 1,4-dihydropyranopyrazoles, tétrahydrobenzo[b]pyranes et β-acétamidoacétones.
dc.type Thesis


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