Composants et potentiel biologique de Cotula anthemoides L et Pentzia monodiana MAIRE. (Asteraceae).

Abstract

The present work concerns the phytochemical and biological studies of areal parts of two Algerian plants belonging to the Asteraceae family: Cotula anthemoides L. and Pentzia monodiana Maire. This study led to the isolation and identification of fifteen compounds of Cotula anthemoides and eight compounds of Pentzia monodiana including five phenolic acids, nine flavonoids from which one is new, three lignans, one sesquiterpene lactone, two glycosyl phenolics, a glycosyl acid, a diterpene and an nucleoside. The structural determination of the isolated compounds was established by the use of 1D and 2D NMR spectroscopic techniques (1H, 13C, COSY, HSQC, HMBC and ROESY), by mass spectrometry (ESI-MS and HRESI-MS) and by comparison with the literature data. The evaluation of the antioxidant activity by 4 methods (DPPH, ABTS, CUPRAC and chelating by ferrous ions) of the various extracts, showed a good activity of extracts from P. monodiana compared to those of C. anthemoides. Furthermore, extracts of C. anthemoides showed an interesting anticholinesterase activity. However, both of lignanes, flavonol and flavones substituted in C-3, exhibited better antityrosinase and antiradical activities than some flavones only.