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Étude phytochimique et biologique de trois espèces Algériennes

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dc.contributor.author Lehbili, Meryem
dc.contributor.author Kabouche, Ahmed
dc.contributor.author Alabdul Magid, Abdulmagid
dc.date.accessioned 2022-05-25T08:23:19Z
dc.date.available 2022-05-25T08:23:19Z
dc.date.issued 2018-07-03
dc.identifier.uri http://depot.umc.edu.dz/handle/123456789/8139
dc.description.abstract The phytochemical study of three species: Calendula stellata, Scabiosa stellata and Salvia barrelieri led to the isolation of 55 compounds, from which 16 were new, by the use of different chromatographic methods of separation and purification on solid or liquid support. The isolated compounds were distributed through 27 saponosids, 7 triterpenes, 11 flavonoids, 7 iridoids and 2 chlorogenic acid derivatives. Two mono-iridoids and two flavonoids showed an important antiradical activity (IC50:7-16 µM). Fourteen compounds exhibited a good antibacterial activity (MIC: 15- 125 µg/mL). The new compounds showed a low to moderate cytotoxic activity against all tested cell lines, except for the monodesmoside, obtained from Scabiosa stellata (Scabiostellatoside F) which exhibited a good antiproliferative effect against HT1080 (IC50 = 12 µM).
dc.language.iso fr
dc.publisher Université Frères Mentouri - Constantine 1
dc.subject Calendula stellata
dc.subject Scabiosa stellata
dc.subject Salvia barrelieri
dc.subject saponosides
dc.subject iridoïdes
dc.subject triterpenoïdes
dc.subject flavonoïdes
dc.subject activité antioxydante
dc.subject activité antimicrobienne
dc.subject cytotoxicité
dc.subject saponosids
dc.subject iridoids
dc.subject triterpenes
dc.subject flavonoids
dc.subject antioxidant activity
dc.subject antimicrobial activity
dc.subject cytotoxicity
dc.subject الفعالیة البیولوجیة
dc.subject مضادة للأكسدة
dc.subject مضادة للبكتیریا
dc.subject سمیة خلویة
dc.title Étude phytochimique et biologique de trois espèces Algériennes
dc.title Calendula stellata Cav. (Asteraceae), Scabiosa stellata L. (Caprifoliaceae) et Salvia barrelieri Etl. (Lamiaceae).
dc.type Thesis

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