Contribution à l’étude phytochimique et biologique de l’espèce Bupleurum lancifolium Hornem.

Abstract

The present work deals with the phytochemical study; the structural determination and biological evaluation of some natural compounds isolated from specie of the Apiaceae family: Bupleurum lancifolium (Hornem). This study led to the isolation and identification of 7 compounds from which 2 compounds are new. The structures of isolated compounds were established particularly by the use of NMR high-field 1D and 2D technics (1H, 13C, COSY H-H, HSQC, HMBC), high resolution mass spectrometry (ESI-MS and HR-ESI-MS), and comparison with literature data : ➢ Un acide phénolique ➢ Deux flavonols glycosilés ➢ Quatre saponosides triterpéniques. The majority of compounds isolated from the butanolic extract of the species B. lancifolium showed a great ability to inhibit the formation of AGEs. The flavonoids isolated from the butanolic extract of stems of B. lancifolium was found to involve a strong inhibition of the formation of of AGEs, while no activity was observed for the saponosids isolated from the butanolic extract of leaves+flowers of B. lancifolium.