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Accès rapide à des hétérocycles polyfonctionnalisés biologiquement actifs via des réactions multicomposants

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dc.contributor.author Mahdjoub, Sara
dc.contributor.author Boulcina, Raouf
dc.date.accessioned 2022-05-25T08:21:03Z
dc.date.available 2022-05-25T08:21:03Z
dc.date.issued 2017-07-09
dc.identifier.uri http://depot.umc.edu.dz/handle/123456789/8097
dc.description.abstract In this manuscript we interested in the development of reactions with multicomponent producing novel molecules through studying the efficiency of new catalysts. This thesis consists of two main parts: The first part has been devoted to the study of the Petasis reaction of and its applications to the synthesis of novel structures which could exhibit interesting biological properties. The first application of the Petasis reaction was the preparation of the novel 2- hydroxy-1,4-benzoxazine derivatives, developing a novel method of synthesis by using an ionic complex which was PPTS as a catalyst. For the second application of the Petasis reaction, a series of novel α-arylglycine derivatives was prepared. In the second part of this work, two new rapid methods have been developed for the synthesis of organophosphorus derivatives via multicomponent reactions. The first developed method was the nanocatalyzed synthesis which has been used for the preparation of (2-amino- 3-cyano-4H-chromen-4-yl) phosphonates derivatives. The second method was microwave-assisted synthesis which has been employed for the preparation of novel pyrazolylphosphonate derivatives. These molecules which are bearing pyrazole skeletons could possess wide variety of pharmacological properties.
dc.language.iso fr
dc.publisher Université Frères Mentouri - Constantine 1
dc.subject réactions à composants multiples
dc.subject Petasis
dc.subject 2-hydroxy-1,4-benzoxazine
dc.subject PPTS
dc.subject α-arylglycines
dc.subject organophosphorés
dc.subject nanocatalyse
dc.subject (2-amino-3-cyano-4H-chromén-4- yl)phosphonates
dc.subject micro-ondes
dc.subject pyrazolylphosphonates
dc.subject multicomponent reactions
dc.subject organophosphorus compounds
dc.subject nanocatalysis
dc.subject microwave
dc.subject التفاعلات المتعددة المكونات
dc.subject بيتاسيس
dc.subject -هيدروكسً-1َ4-بينزأوكسازين
dc.subject الألفا-أريلجيسين
dc.subject المشتقات الفسفوريٌ العضويٌ
dc.subject المحفزات بحجم النانو
dc.subject مشتقات الفسفونات من )2-أمينو- 3-سيانو-4ه-كرومين-4-يل(
dc.subject الميكروويف
dc.subject بيرانوليل فوسفات
dc.title Accès rapide à des hétérocycles polyfonctionnalisés biologiquement actifs via des réactions multicomposants
dc.title.alternative Synthèse des 1,4-benzoxazines, α-aminoacides, 4Hchromenylphosphonates et pyrazolylphosphonates.
dc.type Thesis

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