Composition chimique et évaluation des activites biologiques des huiles essentielles de Pistacia atlantica Desf.et de Ferula vesceritensis Coss. & Dur. et synthese catalytique de nouveaux dérivés pipéridiniques

Abstract

In a first part we studied the chemical composition and biological activities of Pistacia atlantica Desf. and Ferula vesceritensis Coss. & Dur. The GC and GC-MS analyses showed that the essential oils of P. atlantica are rich in α-pinene, limonene and spatulenol, while β-phellandrene, α-terpinene, β-elemene, γ-gurjunene and germacrene-B were found as major components, for the first time for the essential oils of the genus Pistacia . α-Pinene and β- pinene were predominant in the essential oils of Ferula vesceritensis; however the first time that α-phellandrene, fenchylacetate, elixene, l'aristolene and cartol were found as main components in the essential oils of the genus Ferula . The both essential oils of P. atlantica . and F. vesceritensis exhibited a good antibacterial activity against clinical isolated bacteria and food borne pathogens. The essential oils of P. atlantica possess an important antioxidant effect which were determined using β-carotene-linoleic acid, DPPH- and ABTS•+ -scavenging activities, metal chelating effect and CUPRAC assays. The essential oils showed a moderate anticholinestérase activity compared with galantamin for the inhibitory activity of principal enzymes of Alzheimer’s disease AChE and BChE. In a second part, we synthesized 12 new piperidine derivatives, which have been achieved through [Cp*Ru]-catalyzed intermolecular coupling of allylic alcohols and propargylic amides with water as the only side product, and demonstrated that the selective oxidativecoupling cinnamyl alcohol derivatives and 2-substituted allylic alcohols. This methodology allows the access to 3,4- and 3,5-disubstituted enamides as valuable scaffolds for the preparation of 3-methylpiperidine derivatives through selective [Cp*Ru] catalyzed alkene hydrogenation.