Removal of Pivaloyl and trityl groups from Tetrazoles and alcohols via Indium, lithium chloride and arene catalyzed lithiation

Abstract

This manuscript encloses three principal parts: the first part, we have described the synthesis of tetrazoles which are a class of heterocycles with a wide range of applications in medicinal chemistry and in material sciences. We report herein a novel efficient process for transforming a wide variety of nitriles into the corresponding tetrazoles in high yield, using a simple and safe protocol. We have reported in the second part, the protection of tetrazoles using pivaloyl chloride, the same reaction is made to protect a wide range of alcohols with trityl chloride giving trityl ethers and pivaloyl tetrazoles in good yields. Finally, we have reported the use of lithium and a catalytic amount of naphthalene to remove the pivaloyl protecting group from tetrazoles under very mild condition we have reported successfully the use of a new catalyst for the detritylation of trityl ethers using indium and lithium chloride generally with very good yields.