Investigation phytochimique et pharmacologique de deux espèces du genre Linaria

Abstract

A bibliographic research on the genus Linaria (Scrophulariaceae), a genus well distributed in Algeria, shows that it has not used for much studies, which encouraged us to undertake this phytochemical investigation of two species which the first is an endemic one for Algeria and Morocco with the absence of biological and phytochemical literature data, whereas the second one is an used plant in traditional medicine for the treatment of certain skin diseases. The separation and purification of the extracts of L. tingitana with various chromatographic techniques, allowed the identification of ten products, and the identification of their structures using spectroscopic methods: four triterpenes (1 pentacyclic triterpene and 3 sterols), four iridoids (1 detected with LC-MS), two flavones and one sugar. The study of Linaria reflexa led the detection with LC-MS of six glycosylated flavonoids and the isolation and the identification of eight products in which 2 are detected by LC-MS: four flavones (2 glycosylated and 2 aglycones), one iridoid, one lignan, one methyl ester and one sugar. The biological tests on antioxidant (in vivo and in vitro), anti-diabetic (in vivo), anti-inflammatory and antimicrobial (in vitro) activities, showed that both plants have remarkable anti-diabetic and anti-inflammatory activities