Synthèse par voie anodique d’hétérocycles à partir de composés azotés diversement substitués

Abstract

The creation of C - C bound link Direct current is for a long time one of the research axles favour chemistry. The heterocycl of the tétrahydroisoquinolines is among classical divisions of organic chemistry belong to alkaloids which develop most faster they occup p a predominating place in the industry of the pharmaceutical products and quite other areas of chemistry. All that was translated by the synthesis o f a big number of new heterocyclic compounds, so the introduction of new functional groupings in structures of tétrahydroisoquinolines for instance, allowed the preparation of a broad variety of these compounds. Our work is dedicated to the converging synt hesis of various THIQs chirales not racémiques in a pyrroloisoquinoline and a tétrahydroprotoberbérine. These two diverting are no oxygen analogues of natural products as ( - ) - crispine A and ( - ) - xylopinine. The chiralité is brought with the aid of the r eaction of Zincke by enlistment of l ’ α - PEA on salt of isoquinolinium. An analytical study allows to define surgical conditions at best and particularly to put in an obvious place a phenomenon of catalysis redox between the radical cation and ions potas sium cyanide. Électrochemical Syntheses of the oxadiazoles from semicarbazone after an analytical study is accomplished with the aid of a electrode of vitreous carbon in methyl alcohol in the presence of LiClO4 (20 g/L) as electrolyte support.