L’effet de trois protocoles anesthesiques sur certains parametres biochimiques

Abstract

The aim of our study was to compare the effect of three anesthetic protocols on certain plasma biochemical parameters order to have a protocol that has the finest effects. We conducted on 35 rats ( Rattus norvegicus) divided into seven groups of 05 different individuals anesthesia under standardized conditions . Three protocols were tested, ketamine alone, ketamine + Acepromazine , Tiletamine + Zolazepam . It seemed possible that these protocols do not generate significant changes in blood biochemical parameters of rats used in this study (GLUCOSE, UREA, CREATININE, AST, ALT, PAL) except that urea was observed an increase in values , which guide us to a suspicion of possible effect of general anesthesia regardless of the protocol on the renal function in laboratory rats . Given the importance of variations observed results, it is difficult to exclude any influence of the injection of ketamine - acepromazine , ketamine alone or tiletamine - zolazépamsur on these variations. We must remain vigilant in the interpretation of the analyte during sedation in these protocols.