Synthesis, characterisation, and application of new functionalized heterocyclic systems for therapeutic and catalytic purposes; Quinoline-heterocycle Hybrids and benzimidazole carbene metal complexes

Abstract

This work describes a thesis that is divided into two chapters. In the first chapter, a synthesis of novel benzimidazolium salts is presented as N-heterocyclic carbene precursors (NHCs), along with the synthesis of their corresponding Ag-NHC and PEPPSI-type Pd-NHC complexes. The antimicrobial and enzyme inhibitory properties of these complexes were evaluated in vitro. Additionally, the catalytic activity of the Pd-NHC complexes was assessed in direct arylation reactions. The results demonstrate the successful development of potent N-heterocyclic carbene complexes with promising prospects for applications in catalysis and the discovery of bioactive molecules. The second chapter focuses on the synthesis of novel polycyclic compounds through a multicomponent reaction, specifically targeting functionalized rigid system quinoline-4H-pyran hybrid derivatives and quinoline-1,4-dihydropyridine-Nsubstituted hybrid derivatives. The biological activity of some of these compounds, specifically their antioxidant and anti-cholinesterase activity, was extensively evaluated and the results were comprehensively presented and analyzed. Further investigation will be conducted to explore the relationship between the chemical structures of these compounds and their biological activities, establishing a structure-activity relationship for future studies.