Abstract:
The aim of this study is to evaluate in-vitro, the biological activities of some flavonoïds
isolated from Varthemia iphionoids (Asteraceae family) aqueous methanol extract. The plant
is a perennial herb, common in mountainous places in many parts of Jordan. The plant is
described in Jordanian folk medicine for the treatment of kidney and gastro-intestinal
disorders. V. iphionoids aqueous methanolic extract afforded sixteen known compounds
(three monoterpenoids, twelve flavonoids and one sterol). The antioxidant activities of five
identified flavonoids: kumatakillin (VA1), Penduletin (VA2), Jeceidine (VA3), 6-
methoxyisokaemfride (VA4) and quercetin 3,3’-Di-O-methyl ether (VA5) were determined.
The results indicated that in anti-hemolytic assay, the five compounds gave a TH50 higher
than standard and the best result was shown with VA2 (TH50 = 60.14 ± 0.72). Moreover, the
evaluation of anticoagulant and thrombolytic potential showed that all the compounds had
significantly prolonged the clotting time and exhibited an important thrombolytic activity
especially the compounds VA1, VA2 and VA3 compared to the control (*** p <0.001)
