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dc.contributor.authorKabouche, Samy
dc.contributor.authorRouabah, Leila
dc.contributor.authorMaza, Rabah
dc.date.accessioned2019-09-09T12:40:55Z
dc.date.available2019-09-09T12:40:55Z
dc.date.issued2019-01-07
dc.identifier.urihttp://hdl.handle.net/123456789/136599
dc.description.abstractPrimary bone tumors are a major public health problem. Osteosarcoma and Ewing's sarcoma are rare diseases that affect children and young adults, and are the result of impaired bone remodeling. Biochemical markers of bone remodeling are used in the diagnosis, prognosis and evaluation of bone metastases, osteoporosis in combination with imaging techniques. However, bone biomarkers of P1NP and PAO formation and those of CTX and TRAP5b bone resorption may be useful in the diagnosis, evaluation and monitoring of osteosarcoma and Ewing's sarcoma. Firstly, we described the epidemiological and therapeutic aspects of bone tumors by a retrospective study at the level of Ibn Badis -Constantine Hospital-University Center in eastern Algeria. In a second step, we assessed serum biochemical markers of PAO and P1NP bone formation and CTX and TRAP5b bone resorption in patients with osteosarcoma (40 cases) and Ewing's sarcoma (34 cases) by the ELISA assay of these biomarkers. The latter showed good performance in the diagnosis of osteosarcoma and Ewing's sarcoma in terms of precision before treatment, and in evaluation and follow-up after neoadjuvant chemotherapy-based treatment. On the other hand, the correlations of these biochemical markers with each other before and after treatment have allowed effective clinical evaluation of patients with both of these most common types of primary bone tumors. All of our work shows a new aspect of the diagnosis, evaluation and monitoring of osteosarcoma and Ewing's sarcoma before these are detectable by medical imaging.fr_FR
dc.language.isofrfr_FR
dc.publisherجامعة الإخوة منتوري قسنطينةfr_FR
dc.subjectOstéosarcomefr_FR
dc.subjectSarcome d’Ewingfr_FR
dc.subjectLes biomarqueurs osseuxfr_FR
dc.subjectDiagnosticTumeurs osseuses primairefr_FR
dc.subjectOsteosarcomafr_FR
dc.subjectEwing sarcomafr_FR
dc.subjectBone biomarquersfr_FR
dc.subjectDiagnosticfr_FR
dc.subjectPrimary bone tumorsfr_FR
dc.subjectساركوما العظمیةfr_FR
dc.subjectساركوما یوینغfr_FR
dc.subjectالعلامات البیوكیمیائیة في العظامfr_FR
dc.subjectتشخیصfr_FR
dc.subjectالاورام الاولیة السرطانیةfr_FR
dc.titleL’intérêt des biomarqueurs osseux dans le diagnostic, le suivi et l’évaluation des tumeurs osseusesfr_FR
dc.title.alternativeL’ostéosarcome et le sarcome d’Ewing.fr_FR
dc.typeThesisfr_FR


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