Synthèse et caractérisation d’imines et benzoquinoléines, active biologiquement.
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The principal objective of this thesis is based on the synthesis of two amide-based quinoléine dérivatives, and seven original organic compounds of imine derivatives [Shiff’s base] of bidentate NO type, tridentate NOO and NNO, tetradentate NNOO. These organic compounds were identified by the proton and carbon 13 NMR mthod. The synthesized compounds were prepared according to known methods. The imine derivative structures were determined from the diffraction data measured on single crystal. The results of study of biological activity [antioxidant activity] are as follows : - The imine derivatives [compound 1, 4 and 7] and the organic compound Q4 showed the best activity with the CUPRAC test. -Compound Q3 showed low trapping activity with the ABTS test. -The organic compounds Q3 and Q4 , and the imine derivative 4 showed a low antiradical activity with the standard DPPH test.
- Doctorat (Chimie)