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dc.contributor.authorZiadi Chibane, Adil
dc.contributor.authorDedache, Abdelmadjid
dc.date.accessioned2019-01-23T12:08:20Z
dc.date.available2019-01-23T12:08:20Z
dc.date.issued2018-09-23
dc.identifier.urihttp://hdl.handle.net/123456789/136513
dc.description.abstractThe work undertaken through this thesis is part of the development of new procedures for the synthesis of molecules of biological interest, through multi-component reactions. The results obtained are presented in three main chapters: -In the first chapter we studied the catalytic effect of aluminum acetylacetonate on a fourcomponent reaction to access to 1,4-dihydropyrano [2,3-c] pyrazoles derivatives and wen proposed the optimal conditions for obtaining them with good yields. -The second chapter was devoted to the catalytic power of the same catalyst on the threecomponent synthesis of tetrahydrobenzo [b] pyrans, which have also been obtained, in general, with good yields. -As for the third chapter, it was devoted to the development of a new pathway to β- acetamidoketones, another class of molecules with interesting biological and medicinal properties, using phenylboronic acid, a Lewis acid catalyst, which has the advantage of being nontoxic, inexpensive and environmentally friendly. The yields obtained are good to excellent. In addition, the inhibitory activities of acetylcholinesterase and butyrylcholinesterase of certain molecules have been examined and proved to be of interest. All the synthesized products were identified by the usual spectrometric analyzes (IR, 1H NMR and 13C NMR).fr_FR
dc.language.isofrfr_FR
dc.publisherجامعة الإخوة منتوري قسنطينةfr_FR
dc.subjectdihydropyrano [2,3- c]pyrazolesfr_FR
dc.subjecttétrahydrobenzo[b]pyranesfr_FR
dc.subjectβ-acétamidocétonesfr_FR
dc.subjectréactions multicomposantsfr_FR
dc.subjectacide phénylboroniquefr_FR
dc.subjectacide de Lewisfr_FR
dc.subjectacétylacétonate d’aluminiumfr_FR
dc.subjectanti acétylcholinestérasefr_FR
dc.subjectanti butyrylcholinestérasefr_FR
dc.subjectβ-acetamido ketonesfr_FR
dc.subjectmulticomponent reactionsfr_FR
dc.subjectphenylboronic acidfr_FR
dc.subjectLewis acidfr_FR
dc.subjectaluminum acetylacetonatefr_FR
dc.subjectanti acetylcholinesterasefr_FR
dc.subjectanti-butyrylcholinesterasefr_FR
dc.subject4 ,1ديهيدروبيرانو[-3،2ج] بيرازولfr_FR
dc.subjectثيثراهيدروبانزو[ب]بيرانfr_FR
dc.subjectبيثأسيثأميدو سيثونfr_FR
dc.subjectتفاعلات متعددة المركباتfr_FR
dc.subjectحمض فينيل بورونيكfr_FR
dc.subjectحمض لويسfr_FR
dc.subjectأسيتسيل أسيثوناث الألمنيومfr_FR
dc.subjectضد الأسيتيل كولين استيراز والبيتيغيل كولين استيرازfr_FR
dc.titleNouvelles voies de Synthèse des 1,4-dihydropyranopyrazoles, tétrahydrobenzo[b]pyranes et β-acétamidoacétones.fr_FR
dc.typeThesisfr_FR


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