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dc.contributor.authorMahdjoub, Sara
dc.contributor.authorBoulcina, Raouf
dc.date.accessioned2017-12-27T11:32:37Z
dc.date.available2017-12-27T11:32:37Z
dc.date.issued2017-07-09
dc.identifier.urihttp://hdl.handle.net/123456789/136233
dc.description.abstractIn this manuscript we interested in the development of reactions with multicomponent producing novel molecules through studying the efficiency of new catalysts. This thesis consists of two main parts: The first part has been devoted to the study of the Petasis reaction of and its applications to the synthesis of novel structures which could exhibit interesting biological properties. The first application of the Petasis reaction was the preparation of the novel 2- hydroxy-1,4-benzoxazine derivatives, developing a novel method of synthesis by using an ionic complex which was PPTS as a catalyst. For the second application of the Petasis reaction, a series of novel α-arylglycine derivatives was prepared. In the second part of this work, two new rapid methods have been developed for the synthesis of organophosphorus derivatives via multicomponent reactions. The first developed method was the nanocatalyzed synthesis which has been used for the preparation of (2-amino- 3-cyano-4H-chromen-4-yl) phosphonates derivatives. The second method was microwave-assisted synthesis which has been employed for the preparation of novel pyrazolylphosphonate derivatives. These molecules which are bearing pyrazole skeletons could possess wide variety of pharmacological properties.fr_FR
dc.language.isofrfr_FR
dc.publisherجامعة الإخوة منتوري قسنطينةfr_FR
dc.subjectréactions à composants multiplesfr_FR
dc.subjectPetasisfr_FR
dc.subject2-hydroxy-1,4-benzoxazinefr_FR
dc.subjectPPTSfr_FR
dc.subjectα-arylglycinesfr_FR
dc.subjectorganophosphorésfr_FR
dc.subjectnanocatalysefr_FR
dc.subject(2-amino-3-cyano-4H-chromén-4- yl)phosphonatesfr_FR
dc.subjectmicro-ondesfr_FR
dc.subjectpyrazolylphosphonatesfr_FR
dc.subjectmulticomponent reactionsfr_FR
dc.subjectorganophosphorus compoundsfr_FR
dc.subjectnanocatalysisfr_FR
dc.subjectmicrowavefr_FR
dc.subjectالتفاعلات المتعددة المكوناتfr_FR
dc.subjectبيتاسيسfr_FR
dc.subject-هيدروكسً-1َ4-بينزأوكسازينfr_FR
dc.subjectالألفا-أريلجيسينfr_FR
dc.subjectالمشتقات الفسفوريٌ العضويٌfr_FR
dc.subjectالمحفزات بحجم النانوfr_FR
dc.subjectمشتقات الفسفونات من )2-أمينو- 3-سيانو-4ه-كرومين-4-يل(fr_FR
dc.subjectالميكروويفfr_FR
dc.subjectبيرانوليل فوسفاتfr_FR
dc.titleAccès rapide à des hétérocycles polyfonctionnalisés biologiquement actifs via des réactions multicomposantsfr_FR
dc.title.alternativeSynthèse des 1,4-benzoxazines, α-aminoacides, 4Hchromenylphosphonates et pyrazolylphosphonatesfr_FR
dc.typeThesisfr_FR


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